The course will be a mix of theory and practice presented by invited expert speakers and abstract-selected participant contributions. Practical sessions will be a mix of academic and commercial demonstrations giving course participants hands-on experience with computational analysis tools. Expected Participants are people working in a DNA laboratory including clinical diagnostic labs involved in DNA sequencing data analysis. Participants are expected to bring their own laptop (PC or Mac) as this will be needed for the Course. Expected knowledge - basic knowledge of molecular biology (DNA, RNA, protein), molecular biology lab technologies (esp. sequencing) and (human) genetics.