COMPLEXIS – the International Conference on Complexity, Future Information Systems and Risk, aims at becoming a yearly meeting place for presenting and discussing innovative views on all aspects of Complex Information Systems, in different areas such as Informatics, Telecommunications, Computational Intelligence, Biology, Biomedical Engineering and Social Sciences. Information is pervasive in many areas of human activity – perhaps all – and complexity is a characteristic of current Exabyte-sized, highly connected and hyper dimensional, information systems. COMPLEXIS 2018 is expected to provide an overview of the state of the art as well as upcoming trends, and to promote discussion about the potential of new methodologies, technologies and application areas of complex information systems, in the academic and corporate world.