The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics. Time: 2:00 pm - 12:00 pm Prices: Academic from: USD 1779.00 Industry from: USD 1779.00 Student from: USD 1451.00 URL: Booking: https://go.evvnt.com/154651-1 Speakers: John Tainer (LBL and MD Anderson Cancer Centre), Tom Blundell (University of Cambridge), Steve Jackson (University of Cambridge), Bruce Stillman (CSHL)